Abstract on Respiratory Outcomes in Neonates Presented at International Meeting

Updated: 5/9/2014

An abstract authored by Neonatology and Pediatric Anesthesiology members Jerrold Lerman, MD, Chief of Clinical Research & Professor of Anesthesiology, University at Buffalo, Satyan Lakshminrusimha, MD, Chief, Division of Neonatology, Women & Children’s Hospital of Buffalo,  Associate Professor, University at Buffalo, and Director, Center for Developmental Biology of the Lung, Munmun Rawat, MBBS, Neonatology Fellow, and Tamer Elattary, MBChB, was presented at the Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting, May 3-6 in Vancouver, BC.

The abstract, titled “Factors Contributing to Post-operative Respiratory Deterioration in Preterm Infants,” sets out to assess respiratory status before and after elective surgery in preterm infants

While working closely to forge stronger ties and improve patient care, Dr. Lerman and Dr. Lakshminrusimha stumbled upon a serious clinical problem in which extremely preterm infants who require minimal respiratory support often deteriorate in respiratory status after elective surgery that prolongs their hospital stay.

“Anesthesiologists use muscle relaxants for many surgeries that neonates require,” said Dr. Lerman.  “It seems that those neonates whose muscle relaxant is not antagonized do much worse than those whose relaxant is antagonized.”

The abstract concludes that intraoperative factors play a major role in the postoperative respiratory deterioration in preterm infants.  Infants exposed to greater mean airway pressures, FiO2, SpO2 and lack of antagonism of the muscle relaxant are associated with prolonged respiratory support and length of stay after elective surgeries in preterm infants.

“This is a previously unrecognized but very serious clinical issue affecting neonates that has not hit the radar screens yet,” said Dr. Lerman.  “It is our hope to explore the need to antagonize all muscle relaxants at the end of surgery in neonates so that their duration of tracheal intubation and time to discharge from the NICU is abbreviated.” 

To read the full abstract, visit http://www.abstracts2view.com/pas/sessionindex.php?day=Sunday (2942, abstract #583).

The Pediatric Academic Societies (PAS) Annual Meeting is the largest international meeting focused on research in child health.  PAS brings together a variety of groups to not only discuss original research, which has been the hallmark of the PAS meeting, but to also discuss how this research can be applied to actual clinical practice in pediatrics. This alliance also provides opportunity to discuss other critical issues that affect child health such as public policy and advocacy.

The members of Great Lakes Anesthesiology are Board Certified anesthesiologists who have received specialized training in pediatric anesthesia to meet the unique needs of children. They supply services for inpatient and outpatient surgical procedures and radiology testing, train residents and fellows, publish cutting edge research and have authored seminal texts that form the basis for pediatric anesthesia training worldwide.  These physicians are among the few nationally that specialize in pediatrics and work together with surgeons and neonatologists to ensure the most advanced medications, techniques and procedures are utilized at Women & Children’s Hospital of Buffalo to deliver state of the art medical care. Visit www.greatlakesanesthesiology.com for more information.

The Division of Neonatology, part of UBMD Pediatrics and affiliated with the University at Buffalo School of Medicine and Biomedical Sciences, is an academic division with a busy, thriving clinical neonatal intensive care service, active research interests, and a long-standing commitment to fellows and residents. As the Regional Perinatal Center for critically ill newborns, the Neonatal division services the eight counties of Western New York and beyond. The 64-bed NICU admits over 740 babies each year and has an average daily census of 52. Visit www.wchob.org/neonatology for more information.