Paper Published in Hepatology is Second Most Cited in 2013

Released: 1/24/2014

Paper authored by Digestive Diseases and Nutrition Center members at Women & Children’s Hospital of Buffalo


A paper authored by Digestive Diseases and Nutrition Center members Lixin Zhu, PhD, Research Director, Susan S. Baker, MD, PhD, Co-Chief, Division of Gastroenterology, Medical Director, Digestive Diseases & Nutrition Center, Professor, University at Buffalo, Robert D. Baker, MD, PhD, Co-Chief, Division of Gastroenterology, Professor, University at Buffalo, Razan Alkhouri, MD, Clinical Assistant Professor, University at Buffalo, and others is the second most highly cited paper published in 2013 in Hepatolog (Impact Factor 12.003), the official journal of the American Association for the Study of Liver Diseases.

This Honor Role for Hepatology identifies the top 10 exemplary papers among the most highly cited in 2013, according to Thomson Institute for Scientific Information (ISI), a multinational media firm that is a research platform for information in the sciences, social sciences, arts, and humanities.

The paper, titled, “Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: A Connection Between Endogenous Alcohol and NASH”, was published in January 2013.  NASH is a serious liver disease associated with obesity. Characterized by metabolic syndrome, hepatic steatosis, and liver inflammation, NASH is believed to be under the influence of the gut microflora.

The paper concludes that the increased abundance of alcohol-producing bacteria in NASH microbiomes, elevated blood-ethanol concentration in NASH patients, and the well-established role of alcohol metabolism in oxidative stress and, consequently, liver inflammation suggest a role for alcohol-producing microbiota in the pathogenesis of NASH. We postulate that the distinct composition of the gut microbiome among NASH, obese, and healthy controls could offer a target for intervention or a marker for disease.  To learn more, go online at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)15273350/homepage/top_10_most_cited.htm

As an American Board of Pediatrics recognized sub-specialty, Gastroenterology is part of UBMD Pediatrics and affiliated with the University at Buffalo School of Medicine and Biomedical Sciences.  Our qualified and diverse team provides evaluation and diagnosis for infants, children and adolescents with diseases involving the gastrointestinal tract and/or liver, as well as nutrition support services.  The division specializes in the diagnosis and treatment of nutritional problems, gastrointestinal problems, including inflammatory bowel disease, reflux disease, diarrhea, constipation and peptic diseases and liver diseases, including hepatitis B and C, autoimmune hepatitis, metabolic liver diseases, preparation for transplant and follow up after transplant. 

Women & Children's Hospital of Buffalo is ranked by US News & World Report in its annual special edition of "Best Children's Hospitals." Gastroenterology at Women & Children’s Hospital of Buffalo is among the ten specialty areas within children's hospitals ranked nationally in this publication for 2012–2013.

For more information about Gastroenterology at Women & Children’s Hospital of Buffalo, please go online at www.wchob.org/GI